Histopathology skin compound nevus with halo reaction. Spitz nevus is a benign melanocytic lesion and also one of the main differential diagnosis of melanoma. The surface may be smooth or slightly papillomatous. Compound melanocytic nevus histopathology filip sokol. Exhibiting nevus cells in the basal region of the epithelium and the adjacent connective tissue. Malignant combined nevus agminatetype combined nevus consisting of a common blue nevus with a junctional spitz nevus a case of combined nevus. The demand for histopathological diagnosis of pigmented lesions has increased steadily over the last 20 years, partly due to the incidence of melanoma and partly because of increased awareness and referrals from general practitioners. Onceexcised, a junctional nevus does nottend to recur. Benign melanocytic naevi in various sites may show unusual histopathological features that may mimic melanoma. Melanocytic nevus, compound, palm, he 40x 4872 compound melanocytic nevus, skin graft. The center tends to be more heavily pigmented than the. Intradermal nevus abbreviated idn, also intradermal melanocytic nevus, is a common benign melanocytic lesion the intradermal nevus is in the large group common nevus. Congenital melanocytic naevus pathology dermnet nz. Nevi are the most common, found in 52% of the cases, followed by melanoma in 25%, primary acquired melanosis pam in 21%, and racial melanosis in 3%.
The chapter also discusses other acquired benign nevi namely, balloon cell nevus, cockarde nevus and nevus spilus. Common terms, including mole, birthmark, and beauty mark, are used to describe nevi, but these terms do not distinguish specific. This makes a unified and systematic approach to melanoma histopathology even more important. Clinical, dermoscopic and histopathological evaluation of. Some sources equate the term mole with melanocytic nevus, but there are also sources that equate the term mole with any nevus form. Differentiation of malignant melanoma from benign nevus. Dr sampurna roy md nevus may recur following inadequate excision shave biopsy of the lesion or after chronic irritation or laser therapy. Naevi from the auricular region, breast, conjunctiva and ankle sometimes have a rather atypical proliferation of melanocytes in the epidermis, often with pagetosis and cytological atypia. Compound nevus abbreviated cn, also compound melanocytic nevus abbreviated cmn, is a common benign melanocytic lesion the compound nevus is in the large group common nevus. Nevus or nevi if multiple is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. Soepronos textbook is available on and includes detailed information on over 600 entities and includes four dvd diskettes with highresolution images that provide a virtual dermatopathology reference and guide.
Age and sex distribution a neurotized nevus may be present at birth or form at any age in an individual. Media in category histopathology of compound nevus the following 7 files are in this category, out of 7 total. Nevus cells melanocytes are normally localized in the basal layer of the epidermis. In the past decades, the recognition of variants of spitz naevus has resulted in a. State of the art, nomenclature, and points of consensus. A melanocytic nevus also known as nevocytic nevus, nevuscell nevus and commonly as a mole is a type of melanocytic tumor that contains nevus cells. The whole lesion underwent excision, and histopathology confirmed a melanocytic compound nevus, including an exophytic epithelial proliferation figure 3. Compound nevi are slightly or markedly raised pigmented papules. Soeprono teaches and practices dermatopathology at loma linda university, school of medicine, department of dermatology. Atypical lentiginous nevus is a peculiar form of dysplastic nevus that is difficult to diagnose.
The early stage is characterized by a subacute eczema with variable focal spongiosis. Histopathology skincompound clarks nevus dysplastic nevus this feature is not available right now. Of note is the confluent growth pattern of junctional nests, which is not uncommon in conjunctival nevi. Compound nevi they occur more commonly in children and adolescents 2. Slightly raised nevus with regular borders and pigment. If provided, the size of the lesion and information as to whether or not it has been sampled in its clinical entirety may have a signi. Histopathology skin compound clarks nevus dysplastic nevus this feature is not available right now. The histological distinction between spitz naevus spitz 1948 and a small group of melanomas which resemble spitz naevus and which are therefore often referred to colloquially as spitzoid melanomas smith et al. Melanocytic nevus, compound, of the skin graft, he 20x 4000 melanocytic nevus, compound, of the skin graft, he 40x 4001 compound melanocytic nevus and seborrhoic keratosis.
It has also been called nevoid lentigo and nevus incipiens. Although histopathology at the current stage remains. Benign acquired nevi the melanocytic proliferations. Among conjunctival tumors, melanocytic lesions represent 53% of all excised conjunctival lesions.
The phenotype of the nevi is usually that of conventional lentiginous junctional or compound nevi, but some lesions may also have a biphenotypic or multiphenotypic appearance with spitzoid and blue nevuslike melanocytic proliferations. Compound spitz nevus with mild atypia thigh 40f 0 ltfu n favor malignant melanoma in situ developing within a spitz shin 37f 6. Compound nevus definition of compound nevus by medical. The lesion is often accompanied with cystic inclusions of epithelium not nevocytes which are. Their proliferation may appear in the epidermis jonctional nevus, in the epidermis and dermis compound nevus or only in the dermis intradermal nevus. The compound nevus of the conjunctiva features nests of nevus cells that are both at the junction of the epithelium and substantia propria and within the substantia propria. Treatment is generally not required for neurotized nevus, unless it presents cosmetic issues. Rather than representing uvinduced mutation, as is the case with most acquired naevi, the congenital melanocytic naevus is thought to arise from rests of melanocytes being left behind on their ascent from the neural crest to the epidermis. Features of both junctional and intradermal nevi i. Histopathology of spitz naevi and spitzoid melanomas. Trichoepithelioma arising in a congenital melanocytic.
Normal epidermis and dermis with intradermal nevus 10xcropped. The latter showed a trichoepitheliomatous pattern, composed of multiple horn cysts lined by stratified squamous epithelium, sometimes with. Histopathology a compound nevus possesses features of both. Because atypical lentiginous nevus manifests clinically as pigmented, asymmetric, multicolored lesions that appear in areas of chronic sun damage, this condition can be confused with melanoma, lentigo simplex, and atypical melanocytic nevus. True congenital naevi affect approximately 1% of neonates and are classified clinically according to size. It is the classical skincoloured mole, elevated from the skins surface, that most people would recognise as such. Media in category histopathology of nevus the following 2 files are in this category, out of 2 total. Age and sex these lesions usully occur in women from 20 to 30 years of age. The prognosis is usually excellent with appropriate treatment, since these moles are generally benign.
Dermoscopic evolution of a congenital combined nevus in childhood combined nevi of the oral mucosa. Histopathology shows a junctional or compound nevus without atypia or regression cooknorris et al. Clinically, a compound nevus is a pigmented papule or a plaque 1. Compound nevi can have an irregular border but are symmetric. Nests of nevus cells are found both at the dermoepidermal junction and within the dermis. Blue nevus bn is a common specimen in routine pathology practice. Dysplastic atypical, clark melanocytic nevi are acquired pigmented melanocytic proliferations of the skin with distinct clinical and histologic features. The compound variant of blue nevus can be distinguished histologically from combined blue nevus, pigmented spindle cell nevus, malignant melanoma, and melanosis due to a regressed malignant melanoma. In some longstanding lesions, conjunctival cysts can be very prominent. A practical approach to the diagnosis of melanocytic lesions. A case of combined desmoplastic trichoepithelioma and. This is a form of melanocytic naevus but it appears to have the same degree of pigmentation as the surrounding skin. Cytologic atypia refers to nuclear alterations, such as nuclear enlargement. Histopathology skincompound clarks nevus dysplastic.
Histopathology of compound nevus wikimedia commons. The six lesions were from three men and three women whose ages ranged from 11 to 51 years mean, 31 years. This chapter presents a broad overview of the histologic features of the common acquired nevus, and histopathology of the common acquired junctional nevus, the common acquired compound nevus and the common acquired dermal nevus. Histopathology a compound nevus possesses features of both a junctional and an intradermal nevus. Cockade nevi are pink to darkly pigmented lesions surrounded by an inner depigmented and outer pigmented rim characteristically visible on the scalp of children and adolescents fig. Our dermatology online brief report hhistopathological. Site most common sites are on the trunk specifically, the back, followed by face and. The lentiginous nevus is a entity which appears to represent the evolution of a lentigo simplex into a junctional and sometimes a compound nevus. Conjunctival cyst formation is a helpful diagnostic feature. In the oral cavity these are known as intramucosal nevi. Dysplastic nevus syndrome an overview sciencedirect topics.
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